The city of Noblestown was founded in the 1770's. Over time, due to the successful businesses in the area (including a sawmill, a flourmill, coal mines, and stone quarries), the population grew. There was an influx of Catholics who moved to the area, many of whom were immigrants from Europe. In order to meet the spiritual needs of the Catholics in the area, Bishop Michael Domenec, the second Bishop of Pittsburgh, established a mission in Noblestown in 1866, and named it after St. Patrick. Fr. James Tahaney, pastor of Immaculate Conception in Washington, visited the mission once a month. Work soon began on building a church, and it was dedicated around 1869. In 1873, the mission of St. Patrick was elevated to the status of a parish, with Fr. James Canevin appointed the first pastor.

In the late 1880's, Fr. Dennis Gallagher, who was then the pastor of St. Patrick, began organizing a mission in McDonald for the growing number of Catholics there. What would eventually become St. Alphonsus Parish started off as a mission of St. Patrick.

In 1892, St. Patrick church burned down. By 1894, it was rebuilt, only to burn down again in 1899 after a lightening strike. The parishioners were persistent, and within a year, the the third St. Patrick church was built and dedicated. It is the same church that stands today. Throughout the years, the parish grew. The parking lot was enlarged in 1957, and the social hall was built in 1960. Tragedy struck on January 1, 1973, when a fire destroyed St. Patrick Rectory, and claimed the life of its pastor, Fr. Thomas Morgan. Parishioners continued to persevere, as they have before. A new rectory was soon built, and over time, various improvements were made to the interior of the church, including the purchase of a new organ, the installation of stained glass windows, and the painting of the Resurrection/Ascension mural above the sanctuary.

History was made in 2008, when Fr. Kenneth Sparks became pastor of both St. Patrick Parish and St. Alphonsus Parish. This was the first time that St. Patrick and St. Alphonsus shared a pastor since Fr. Gallagher had first organized St. Alphonsus as a mission of St. Patrick over a hundred years prior. Although the pastors would change, St. Patrick and St. Alphonsus would to continue to share a pastor all the way up until they become part of the new St. Isidore the Famrer Parish in 2020, where the work of spreading the Gospel continues to this day.